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Vitamin D supplementation modulates glycated hemoglobin (HBA1c) in diabetes mellitus.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, 11790, United States. Electronic address: fnu.asma.1@stonybrook.edu. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, 2440, Saudi Arabia. Electronic address: s.alouffi@uoh.edu.sa. Department of Biochemistry, King George Medical University, Lucknow, U.P., India. Electronic address: uzmashahab@gmail.com. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, 2440, Saudi Arabia. Electronic address: rihabakasha@gmail.com. Department of Zoology, Aligarh Muslim University, Aligarh, India. Electronic address: mf.rehman5681@gmail.com. Department of Internal Medicine, College of Medicine, University of Hail, 2440, Saudi Arabia; Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt. Electronic address: mo.ghonim@uoh.edu.sa. Department of Computer Science and Information System, College of Applied Sciences, AlMaarefa University, P.O.Box 71666, Riyadh, 13713, Saudi Arabia. Electronic address: nahmad@um.edu.sa. University Centre for Research and Development, Chandigarh University, Mohali, Punjab, India. Electronic address: kirtanjot@gmail.com. School of Health Sciences and Technology (SOHST), UPES, Dehradun, 248007, Uttarakhand, India. Electronic address: ramendra.pandey@gmail.com. Department of Internal Medicine, College of Medicine, University of Hail, Saudi Arabia. Electronic address: ahmed.alshammari@uoh.edu.sa. Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, 11790, United States. Electronic address: fnu.firozakhter@stonybrook.edu. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, 2440, Saudi Arabia. Electronic address: s.ansari@uoh.edu.sa.

Archives of biochemistry and biophysics. 2024;:109911
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Abstract

Diabetes is a metabolic illness that increases protein glycosylation in hyperglycemic conditions, which can have an impact on almost every organ system in the body. The role of vitamin D in the etiology of diabetes under RAGE (receptor for advanced glycation end products) stress has recently received some attention on a global scale. Vitamin D's other skeletal benefits have generated a great deal of research. Vitamin D's function in the development of type 1 and type 2 diabetes is supported by the discovery of 1,25 (OH)2D3 and 1-Alpha-Hydroylase expression in immune cells, pancreatic beta cells, and several other organs besides the bone system. A lower HBA1c level, metabolic syndrome, and diabetes mellitus all seems to be associated with vitamin D insufficiency. Most of the cross-sectional and prospective observational studies that were used to gather human evidence revealed an inverse relationship between vitamin D level and the prevalence or incidence of elevated HBA1c in type 2 diabetes. Several trials have reported on the impact of vitamin D supplementation for glycemia or incidence of type 2 diabetes, with varying degrees of success. The current paper examines the available data for a relationship between vitamin D supplementation and HBA1c level in diabetes and discusses the biological plausibility of such a relationship.

Methodological quality

Publication Type : Review

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